Integrated MRI-guided radiotherapy—opportunities and challenges

PJ Keall, C Brighi, C Glide-Hurst, G Liney… - Nature Reviews …, 2022 - nature.com
MRI can help to categorize tissues as malignant or non-malignant both anatomically and
functionally, with a high level of spatial and temporal resolution. This non-invasive imaging …

Adaptive radiotherapy for anatomical changes

JJ Sonke, M Aznar, C Rasch - Seminars in radiation oncology, 2019 - Elsevier
The anatomy of cancer patients changes between radiation treatment planning and delivery
as well as over the course of radiotherapy. Adaptive radiotherapy (ART) aims to deliver …

[HTML][HTML] Adaptive radiotherapy: the Elekta Unity MR-linac concept

D Winkel, GH Bol, PS Kroon, B van Asselen… - Clinical and translational …, 2019 - Elsevier
Background and purpose The promise of the MR-linac is that one can visualize all
anatomical changes during the course of radiotherapy and hence adapt the treatment plan …

[HTML][HTML] Phase I trial of stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of oligometastatic or unresectable primary malignancies of …

L Henke, R Kashani, C Robinson, A Curcuru… - Radiotherapy and …, 2018 - Elsevier
Purpose/objectives SBRT is used to treat oligometastatic or unresectable primary abdominal
malignancies, although ablative dose delivery is limited by proximity of organs-at-risk (OAR) …

Roadmap: proton therapy physics and biology

H Paganetti, C Beltran, S Both, L Dong… - Physics in Medicine …, 2021 - iopscience.iop.org
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

The transformation of radiation oncology using real-time magnetic resonance guidance: A review

WA Hall, ES Paulson, UA van der Heide… - European Journal of …, 2019 - Elsevier
Radiation therapy (RT) is an essential component of effective cancer care and is used
across nearly all cancer types. The delivery of RT is becoming more precise through rapid …

Medical physics challenges in clinical MR-guided radiotherapy

C Kurz, G Buizza, G Landry, F Kamp, M Rabe… - Radiation …, 2020 - Springer
The integration of magnetic resonance imaging (MRI) for guidance in external beam
radiotherapy has faced significant research and development efforts in recent years. The …

[HTML][HTML] Prostate intrafraction motion during the preparation and delivery of MR-guided radiotherapy sessions on a 1.5 T MR-Linac

DM de Muinck Keizer, LGW Kerkmeijer… - Radiotherapy and …, 2020 - Elsevier
Purpose To evaluate prostate intrafraction motion using MRI during the full course of online
adaptive MR-Linac radiotherapy (RT) fractions, in preparation of MR-guided extremely …

[HTML][HTML] Stereotactic MR-guided online adaptive radiation therapy (SMART) for ultracentral thorax malignancies: results of a phase 1 trial

LE Henke, JR Olsen, JA Contreras, A Curcuru… - Advances in radiation …, 2019 - Elsevier
Purpose Stereotactic body radiation therapy (SBRT) is an effective treatment for
oligometastatic or unresectable primary malignancies, although target proximity to organs at …

[HTML][HTML] Feasibility of stereotactic radiotherapy using a 1.5 T MR-linac: Multi-fraction treatment of pelvic lymph node oligometastases

AM Werensteijn-Honingh, PS Kroon, D Winkel… - Radiotherapy and …, 2019 - Elsevier
Online adaptive radiotherapy using the 1.5 Tesla MR-linac is feasible for SBRT (5× 7 Gy) of
pelvic lymph node oligometastases. The workflow allows full online planning based on daily …