After three decades of developments, single particle tracking (SPT) has become a powerful
tool to interrogate dynamics in a range of materials including live cells and novel catalytic …

Morphine and related µ-opioid receptor (MOR) agonists remain among the most effective
drugs known for acute relief of severe pain. A major problem in treating painful conditions is …

The spatiotemporal organization and dynamics of chromatin play critical roles in regulating
genome function. However, visualizing specific, endogenous genomic loci remains …

Although the highly dynamic and mosaic organization of the plasma membrane is well-
recognized, depicting a resolved, global view of this organization remains challenging. We …

G-protein–coupled receptors (GPCRs) are the largest family of transmembrane signaling
proteins in the human genome. Events in the GPCR signaling cascade have been well …

Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

Neurotransmitter receptor movement into and out of synapses is one of the core
mechanisms for rapidly changing the number of functional receptors during synaptic …

Visualization of chromosomal dynamics is important for understanding many fundamental
intra-nuclear processes. Efficient and reliable live-cell multicolor labeling of chromosomal …

Molecules undergo non-Brownian diffusion in the plasma membrane, but the mechanism
behind this anomalous diffusion is controversial. To characterize the anomalous diffusion in …

The actin cytoskeleton has been implicated in restricting diffusion of plasma membrane
components. Here, simultaneous observations of quantum dot-labelled FcɛRI motion and …