Aortic aneurysms: current pathogenesis and therapeutic targets

MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …

Endothelial dysfunction in the pathogenesis of abdominal aortic aneurysm

E DeRoo, A Stranz, H Yang, M Hsieh, C Se, T Zhou - Biomolecules, 2022 - mdpi.com
Abdominal aortic aneurysm (AAA), defined as a focal dilation of the abdominal aorta beyond
50% of its normal diameter, is a common and potentially life-threatening vascular disease …

Abdominal aortic aneurysm and cardiometabolic traits share strong genetic susceptibility to lipid metabolism and inflammation

S Zheng, PS Tsao, C Pan - Nature communications, 2024 - nature.com
Abdominal aortic aneurysm has a high heritability and often co-occurs with other
cardiometabolic disorders, suggesting shared genetic susceptibility. We investigate this …

The contribution of matrix metalloproteinases and their inhibitors to the development, progression, and rupture of abdominal aortic aneurysms

G Atkinson, R Bianco, K Di Gregoli… - Frontiers in …, 2023 - frontiersin.org
Abdominal aortic aneurysms (AAAs) account for up to 8% of deaths in men aged 65 years
and over and 2.2% of women. Patients with AAAs often have atherosclerosis, and intimal …

Thrombospondin-1 in vascular development, vascular function, and vascular disease

B Liu, H Yang, YS Song, CM Sorenson… - Seminars in Cell & …, 2024 - Elsevier
Angiogenesis is vital to developmental, regenerative and repair processes. It is normally
regulated by a balanced production of pro-and anti-angiogenic factors. Alterations in this …

Single-cell RNA sequencing reveals the pathogenic relevance of intracranial atherosclerosis in blood blister-like aneurysms

D Wen, X Wang, R Chen, H Li, J Zheng, W Fu… - Frontiers in …, 2022 - frontiersin.org
Background Intracranial non-branching site blood blister-like aneurysms (BBA) are
extremely rare and vicious. Their etiology remains elusive, and no molecular study has been …

Mechanisms of abdominal aortic aneurysm progression: A review

JP Gao, W Guo - Vascular Medicine, 2022 - journals.sagepub.com
Abdominal aortic aneurysm (AAA) is a common disease associated with significant
cardiovascular morbidity and mortality. Up to now, there is still controversy on the choice of …

Early Progression of Abdominal Aortic Aneurysm is Decelerated by Improved Endothelial Barrier Function via ALDH2‐LIN28B‐ELK3 Signaling

K Yang, S Cui, J Wang, T Xu, H Du, H Yue… - Advanced …, 2023 - Wiley Online Library
The involvement of endothelial barrier function in abdominal aortic aneurysm (AAA) and its
upstream regulators remains unknown. Single‐cell RNA sequencing shows that disrupted …

[HTML][HTML] Integrative analysis of single-Cell RNA sequencing and experimental validation in the study of abdominal aortic aneurysm progression

J Xiong, G Chen, B Lin, L Zhong, X Jiang, H Lu - Gene, 2024 - Elsevier
Background Abdominal aortic aneurysm (AAA) is a complex vascular disorder characterized
by the progressive dilation of the abdominal aorta, with a high risk of rupture and mortality …

FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination

C Lei, H Kan, X Xian, W Chen, W Xiang, X Song… - Nature …, 2023 - nature.com
Reprogramming of vascular smooth muscle cell (VSMC) differentiation plays an essential
role in abdominal aortic aneurysm (AAA). However, the underlying mechanisms are still …