Cellular and molecular mechanisms of Hedgehog signalling
The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning,
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
postembryonic tissue regeneration, and cancer, yet aspects of Hedgehog signal …
Mechanisms and functions of Hedgehog signalling across the metazoa
PW Ingham, Y Nakano, C Seger - Nature reviews genetics, 2011 - nature.com
Hedgehog proteins constitute one of a small number of families of secreted signals that have
a central role in the development of metazoans. Genetic analyses in flies, fish and mice have …
a central role in the development of metazoans. Genetic analyses in flies, fish and mice have …
Structural basis for cholesterol transport-like activity of the hedgehog receptor patched
Hedgehog protein signals mediate tissue patterning and maintenance by binding to and
inactivating their common receptor Patched, a 12-transmembrane protein that otherwise …
inactivating their common receptor Patched, a 12-transmembrane protein that otherwise …
The Hedgehog signal transduction network
Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …
and adult structures, and disruption of Hh signaling pathways results in various human …
Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation
The past decade of research on Drosophila stem cells and niches has provided key insights.
Fly stem cells do not occupy a special" state" based on novel" stem cell genes" but resemble …
Fly stem cells do not occupy a special" state" based on novel" stem cell genes" but resemble …
Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia
Hedgehog (Hh) signalling is important in development, stem cell biology and disease. In a
variety of tissues, Hh acts as a morphogen to regulate growth and cell fate specification …
variety of tissues, Hh acts as a morphogen to regulate growth and cell fate specification …
[HTML][HTML] Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function
BL Allen, JY Song, L Izzi, IW Althaus, JS Kang… - Developmental cell, 2011 - cell.com
Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1).
However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1 …
However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1 …
Interactions between Hedgehog proteins and their binding partners come into view
PA Beachy, SG Hymowitz, RA Lazarus… - Genes & …, 2010 - genesdev.cshlp.org
Hedgehog (Hh) proteins are secreted signaling molecules that mediate essential tissue-
patterning events during embryonic development and function in tissue homeostasis and …
patterning events during embryonic development and function in tissue homeostasis and …
Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened
Hedgehog (Hh) signaling regulates embryonic development and adult tissue homeostasis
through the GPCR-like protein Smoothened (Smo), but how vertebrate Smo is activated …
through the GPCR-like protein Smoothened (Smo), but how vertebrate Smo is activated …
[HTML][HTML] Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation
L Izzi, M Lévesque, S Morin, D Laniel, BC Wilkes… - Developmental cell, 2011 - cell.com
Hedgehog (Hh) proteins regulate important developmental processes, including cell
proliferation and differentiation. Although Patched acts as the main Hh receptor in …
proliferation and differentiation. Although Patched acts as the main Hh receptor in …