Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the
pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is …

The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/Nrf2) is a pivotal facilitator of
cytoprotective responses against the oxidative/electrophilic insults. Upon activation, Nrf2 …

Aim Interruption to blood flow causes ischemia and infarction of brain tissues with
consequent neuronal damage and brain dysfunction. Pomegranate extract is well tolerated …

Transient receptor potential melastatin-2 (TRPM2) channels are cation channels activated
by oxidative stress and ADP-ribose (ADPR). Role of TRPM2 channels has been postulated …

Generally accepted, inflammation and neuron apoptosis are two characterized pathological
features of cerebral ischemia-reperfusion (IR) injury. Ginsenoside Rg1 was reported …

The present study compared the potential neuroprotective effects of tanshinone (Tan) IIA
monotherapy, tetramethylpyrazine (TMP) monotherapy, and Tan IIA+ TMP combination …

Our early experiments confirmed that D-allose was closely involved in the blood brain
barrier (BBB) protection from ischemia reperfusion (IR) injury, but the regulatory mechanism …

BACKGROUND: There is evidence that exercise decreases ischemia/reperfusion injury in
rats. Since behavioral deficits are the main outcome in patients after stroke, our study was …

Macrophages play essential roles during the progression of chronic liver disease. They
actively participate in the response to liver damage and in the balance between fibrogenesis …

Endoplasmic reticulum (ER) stress has been postulated to play a crucial role in the
pathophysiology of cerebral ischemic/reperfusion (I/R) injury and diabetes. Diabetes is a …