Initially produced in Europe in 1958, metformin is still one of the most widely prescribed
drugs to treat type II diabetes and other comorbidities associated with insulin resistance …

Reproduction is an energy demanding function and only take place in case of sufficient
available energy status in mammals. Metabolic diseases such as anorexia nervosa are …

Recent advances in human blastoids have opened new avenues for modeling early human
development and implantation. One limitation of our first protocol for human blastoid …

Adenosine monophosphate-activated protein kinase (AMPK), a crucial molecule in energy
metabolism, is reported to play a potential role in gut epithelial differentiation and barrier …

Suboptimal uterine fluid (UF) composition can lead to pregnancy loss and likely contributes
to offspring susceptibility to chronic adult-onset disorders. However, our understanding of …

Aberrant epigenetic reprogramming is a major factor of developmental failure of cloned
embryos. Histone H3 lysine 27 trimethylation (H3K27me3), a histone mark for transcriptional …

Cell-cell junctions form strong intercellular connections and mediate communication
between blastomeres during preimplantation embryonic development and thus are crucial …

Obesity is associated with altered fatty acid profiles, reduced fertility, and assisted
reproductive technology (ART) success. The effects of palmitic acid (PA), oleic acid (OA) …

Claudin 1 is a member of the claudin protein family that serves an important role in tight
junctions. Increased or decreased expression levels of claudin 1 are found in several …

Understanding preimplantation embryo development has important implications for assisted
reproductive technologies (ARTs) after the introduction of in vitro fertilisation and embryo …