Herein, we review the epitope approach to vaccine development, and discuss how
knowledge of HLA supertypes might be used as a tool in the development of such vaccines …

Recent developments have led to a clearer understanding of the association between
peptides and MHC molecules. It is now clear that the peptides presented by MHC class I or …

A large fraction of HLA class I, and possibly class II, molecules can be classified into
relatively few supertypes, characterized by overlapping peptide-binding repertoires and …

An HLA-A3-like supertype (minimally comprised of products from the HLA class I alleles A3,
A11, A31, A∗ 3301, and A∗ 6801) has been defined on the basis of (a) structural similarities …

MATERIALS AND METHODS Cells and Antisera. HLA-B44 molecules were isolated from
the human plasma cell line Hmy2. ClR deficient in class I expression (Zemmour et al., 1992) …

The peptide-binding motif of HLA-A29, the predisposing allele for birdshot retinopathy, was
determined after acid-elution of endogenous peptides from purified HLA-A29 molecules …

Human leukocyte antigens (HLA) have long been grouped into supertypes to facilitate
peptide‐based immunotherapy. Analysis of several hundreds of peptides presented by all …

We selected for study a set of B44-supertype molecules collectively represented in> 40% of
the individuals in all major ethnicities (B* 1801, B* 4001, B* 4002, B* 4402, B* 4403, and B …

Synthetic approaches to T-cell epitope determination have recently been developed that
complement the search for natural T-cell epitopes and the investigation of the preferences of …

The nature of the immunopathogenic relationship underlying the very strong association of
coeliac disease (CD) to the HLA‐DQ (A1* 0501, B1* 0201) genotype is not known, but …