Abstract Oestrogen receptor-positive (ER+) breast cancer is a major cause of cancer death
in women. Although aromatase inhibitors suppress the function of ER and reduce the risk of …

Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …

The successful use of high dose synthetic estrogens to treat post-menopausal metastatic
breast cancer, is the first effective “chemical therapy” proven in clinical trial to treat any …

Simple Summary Estrogen is known to drive the growth of estrogen-receptor-positive breast
cancers, the most common breast cancer subtype. Drugs that target the estrogen receptor by …

The discovery of 17β-estradiol (E2)–induced apoptosis has clinical relevance.
Mechanistically, E2 over activates nuclear estrogen receptor α that results in stress …

The translational research strategy of targeting estrogen receptor α (ERα) positive breast
cancer and then using long term anti-hormone adjuvant therapy (5-10 years) has reduced …

Breast cancer is the most common malignancy in women worldwide. With the increasing
awareness of heterogeneity in breast cancers, better prediction of breast cancer prognosis is …

Purpose Current concepts regarding estrogen and its mechanistic effects on breast cancer
in women are evolving. This article reviews studies that address estrogen-mediated breast …

Prostate cancer is one of the leading causes of cancer mortality in men worldwide. An
unusual but unique environment for studying tumor cell processes is provided by …

We investigated the association between c-Src and the progression of hepatocellular
carcinoma (HCC) and its underlying mechanisms. The relationship between c-Src …