Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
Vascular endothelial cell development and diversity
E Trimm, K Red-Horse - Nature Reviews Cardiology, 2023 - nature.com
Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …
in the development and maintenance of the functional circulatory system and provide …
Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation
Directed differentiation of human pluripotent stem cells to kidney organoids brings the
prospect of drug screening, disease modelling and the generation of tissue for renal …
prospect of drug screening, disease modelling and the generation of tissue for renal …
Basic and therapeutic aspects of angiogenesis updated
G Eelen, L Treps, X Li, P Carmeliet - Circulation research, 2020 - Am Heart Assoc
All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …
Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature
Human organoids, self-organized and differentiated from homogenous pluripotent stem cells
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …
Flow-enhanced vascularization and maturation of kidney organoids in vitro
Kidney organoids derived from human pluripotent stem cells have glomerular-and tubular-
like compartments that are largely avascular and immature in static culture. Here we report …
like compartments that are largely avascular and immature in static culture. Here we report …
Rethinking organoid technology through bioengineering
In recent years considerable progress has been made in the development of faithful
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …
procedures for the differentiation of human pluripotent stem cells (hPSCs). An important step …
Kidney decellularized extracellular matrix enhanced the vascularization and maturation of human kidney organoids
JW Kim, SA Nam, J Yi, JY Kim, JY Lee… - Advanced …, 2022 - Wiley Online Library
Kidney organoids derived from human pluripotent stem cells (hPSCs) have extensive
potential for disease modelling and regenerative medicine. However, the limited …
potential for disease modelling and regenerative medicine. However, the limited …
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery
Human pluripotent stem-cell-derived organoids are models for human development and
disease. We report a modified human kidney organoid system that generates thousands of …
disease. We report a modified human kidney organoid system that generates thousands of …
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation
Accumulating evidence demonstrates important roles for metabolism in cell fate
determination. However, it is a challenge to assess metabolism at a spatial resolution that …
determination. However, it is a challenge to assess metabolism at a spatial resolution that …