FAPI PET/CT in diagnostic and treatment management of colorectal cancer: review of current research status

Z Cheng, S Wang, S Xu, B Du, X Li, Y Li - Journal of Clinical Medicine, 2023 - mdpi.com
FAPI PET/CT is a novel imaging tool targeting fibroblast activation protein (FAP), with high
tumor uptake rate and low background noise. Therefore, the appearance of FAPI PET/CT …

Head-To-Head Comparison of 68Ga-FAPI PET/CT and FDG PET/CT for the Detection of Peritoneal Metastases: Systematic Review and Meta-Analysis

Z Gege, W Xueju, J Bin - American Journal of …, 2023 - Am Roentgen Ray Soc
Please see the Editorial Comment by Sree Harsha Tirumani discussing this article.
BACKGROUND. FDG PET/CT has limited diagnostic performance in the detection of …

Consensus molecular subtype 4 (CMS4)-targeted therapy in primary colon cancer: a proof-of-concept study

NA Peters, A Constantinides, I Ubink, J van Kuik… - Frontiers in …, 2022 - frontiersin.org
Background Mesenchymal Consensus Molecular Subtype 4 (CMS4) colon cancer is
associated with poor prognosis and therapy resistance. In this proof-of-concept study, we …

Fibroblast activation protein-α (FAP) identifies stromal invasion in colorectal neoplasia

A Tarín-Nieto, JD Solano-Iturri… - The American Journal …, 2023 - journals.lww.com
The increasing detection of colorectal adenomas and early adenocarcinomas (ADCs) in the
context of nationwide screening programs has led to a significant increase in the incidence …

From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment

Z Zhang, J Tao, J Qiu, Z Cao, H Huang, J Xiao… - Cellular Oncology, 2024 - Springer
Purpose This study aims to review the multifaceted roles of a membrane protein named
Fibroblast Activation Protein (FAP) expressed in tumor tissue, including its molecular …

Stromal localization of inactive CD8+ T cells in metastatic mismatch repair deficient colorectal cancer

E Küçükköse, MJD Baars, M Amini, SJ Schraa… - British Journal of …, 2024 - nature.com
Background The determinants of metastasis in mismatch repair deficiency with high levels of
microsatellite instability (MSI-H) in colorectal cancer (CRC) are poorly understood. Here, we …

Clinical challenges of consensus molecular subtype CMS4 colon cancer in the era of precision medicine

S Mouillet-Richard, A Cazelles, M Sroussi… - Clinical Cancer …, 2024 - AACR
Over the past decade, our understanding of the diversity of colorectal cancer has expanded
significantly, raising hopes of tailoring treatments more precisely for individual patients. A …

Exploring the efficacy of FAPI PET/CT in the diagnosis and treatment management of colorectal cancer: a comprehensive literature review and initial experience

H Dadgar, N Norouzbeigi, E Jafari… - Clinical and …, 2024 - Springer
Abstract FAPI PET/CT, an innovative medical imaging technique, has emerged as a
promising method to target fibroblast activation protein (FAP). This novel approach offers …

[68Ga]Ga-FAPI-04 PET/MR imaging strategy in management of Krukenberg tumors (KTs) from gastric signet-ring-cell carcinoma: to overcome limitation of [68Ga]Ga …

T Wang, G Huang, H Zhao, L Li, Y Shen, W Lou… - European Journal of …, 2024 - Springer
Purpose To compare performance of whole-body [68Ga] Ga-FAPI-04 and [18F] FDG PET
imaging in the detection of Krukenberg tumors (KTs), primary site and extra-ovarian …

First-line palliative systemic therapy alternated with oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy for unresectable colorectal peritoneal …

P Rauwerdink, VCJ van de Vlasakker… - European Journal of …, 2024 - Elsevier
Background Palliative systemic therapy alternated with electrostatic precipitation oxaliplatin-
based pressurized intraperitoneal aerosol chemotherapy (ePIPAC) has never been …