Altered metabolism and deregulated cellular energetics are now considered a hallmark of
all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

The addition of O-linked-β-DN-acetylglucosamine (O-GlcNAc) onto serine and threonine
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …

Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that
occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of …

The vast array of cell types of multicellular organisms must individually fine-tune their
internal metabolism. One important metabolic and stress regulatory mechanism is the …

The development of the foetal heart is driven by increased glucose uptake and activation of
mammalian target of rapamycin (mTOR) and hypoxia‐inducible factor‐1α (HIF‐1α), which …

Glycosyltransferases are a superfamily of enzymes that are notoriously difficult to inhibit.
Here we apply an mRNA display technology integrated with genetic code reprogramming …

Mechanical interactions between tumors and the extracellular matrix (ECM) of the
surrounding tissues have profound effects on a wide variety of cellular functions. An …

Neurodegenerative diseases such as Alzheimer's and Parkinson's remain highly prevalent
and incurable disorders. A major challenge in fully understanding and combating the …