Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality.
Causes are ill defined but could be through direct cardiac infection and/or inflammation …

Fibrosis of visceral organs such as the lungs, heart, kidneys and liver remains a major cause
of morbidity and mortality and is also associated with many other disorders, including cancer …

The aberrant production of collagen by fibroblasts is a hallmark of many solid tumours and
can influence cancer progression. How the mesenchymal cells in the tumour …

Background Accumulation of extracellular matrix in organs and tissues is a feature of both
aging and disease. In the kidney, glomerulosclerosis and tubulointerstitial fibrosis …

Fibrosis, stiffening and scarring of an organ/tissue due to genetic abnormalities,
environmental factors, infection, and/or injury, is responsible for> 40% of all deaths in the …

Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix
proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified …

The deep fascia is a three‐dimensional continuum of connective tissue surrounding the
bones, muscles, nerves and blood vessels throughout our body. Its importance in chronically …