Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Chromatin, the physiological template of all eukaryotic genetic information, is subject to a
diverse array of posttranslational modifications that largely impinge on histone amino …

The functional significance of mono-, di-, and trimethylation of lysine residues within histone
proteins remains unclear. Antibodies developed to selectively recognize each of these …

Epigenetic dysregulation is a prominent feature in cancer, as exemplified by frequent
mutations in chromatin regulators, including the MLL/KMT2 family of histone …

Given that cocaine induces neuroadaptations through regulation of gene expression, we
investigated whether chromatin remodeling at specific gene promoters may be a key …

Diverse post-translational modifications of histone amino termini represent an important
epigenetic mechanism for the organisation of chromatin structure and the regulation of gene …

Histones are a major component of chromatin, the protein-DNA complex fundamental to
genome packaging, function, and regulation. A fraction of histones are nonallelic variants …

Proper partitioning of the contents of a cell between two daughters requires integration of
spatial and temporal cues. The anaphase array of microtubules that self-organize at the …

Aurora B is a mitotic protein kinase that phosphorylates histone H3, behaves as a
chromosomal passenger protein, and functions in cytokinesis. We investigated a role for …

We describe the design and performance of a prototype high performance hybrid mass
spectrometer. This instrument consists of a linear quadrupole ion trap (QLT) coupled to a …