The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a
carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized …

The excessive use of antibiotics has led to a rise in drug-resistant bacteria. These
“superbugs” are continuously emerging and becoming increasingly harder to treat. As a …

Metal-binding proteins (MBPs) have various and important biological roles in all living
species and many human diseases are intricately linked to dysfunctional MBPs. Here, we …

New Delhi metallo-β-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all β-lactam
antibiotics, posing an emerging threat to public health. There are currently less effective …

Overcoming antimicrobial resistance represents a formidable challenge and investigating
bacterial growth inhibition by fungal metabolites may yield new strategies. Although the …

New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …

Antimicrobial stewardship is imperative when treating bacterial infections because the
misuse and overuse of antibiotics have caused pathogens to develop life-threatening …

Antibacterial drug resistance is a rapidly growing clinical threat, partially due to expression
of β-lactamase enzymes, which confer resistance to bacteria by hydrolyzing and inactivating …

Some antibiotics that are frequently employed are β-lactams. In light of the hydrolytic
process of β-lactamase, found in Gram-negative bacteria, inhibitors of β-lactamase (BLIs) …

The emergence and dissemination of metallo-β-lactamases (MBLs) producing
Enterobacterales is a great concern for public health due to the limited therapeutic options …