Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …

The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …

Evidence on the validity of drug targets from randomized trials is reliable but typically
expensive and slow to obtain. In contrast, evidence from conventional observational …

Background Sepsis is characterised by dysregulated, life-threatening immune responses,
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …

Importance Mendelian randomization (MR) is a statistical approach that has become
increasingly popular in the field of cardiovascular disease research. It offers a way to infer …

Importance Clinical trial data have called into question the efficacy of thiazide diuretics for
the prevention of kidney stones. Objective To identify whether there is an association …

There is increasing evidence for inflammation as a determinant in the pathogenesis of
Parkinson's disease, but its role in parkinsonian neurodegeneration remains elusive. It is not …

Background Prostate cancer (PrCa) is the second most prevalent malignancy in men
worldwide. Observational studies have linked the use of low-density lipoprotein cholesterol …

Background: Lipoprotein-related traits have been consistently identified as risk factors for
atherosclerotic cardiovascular disease, largely on the basis of studies of coronary artery …