Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses

LN Vandenberg, T Colborn, TB Hayes… - Endocrine …, 2012 - academic.oup.com
For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional
concepts in toxicology, in particular the dogma of “the dose makes the poison,” because …

Chlorinated persistent organic pollutants, obesity, and type 2 diabetes

DH Lee, M Porta, DR Jacobs Jr… - Endocrine …, 2014 - academic.oup.com
Persistent organic pollutants (POPs) are lipophilic compounds that travel with lipids and
accumulate mainly in adipose tissue. Recent human evidence links low-dose POPs to an …

Feedback regulation of EGFR signalling: decision making by early and delayed loops

R Avraham, Y Yarden - Nature reviews Molecular cell biology, 2011 - nature.com
Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …

[HTML][HTML] Ligand-receptor promiscuity enables cellular addressing

CJ Su, A Murugan, JM Linton, A Yeluri, J Bois… - Cell systems, 2022 - cell.com
In multicellular organisms, secreted ligands selectively activate, or" address," specific target
cell populations to control cell fate decision-making and other processes. Key cell-cell …

Studies into β-glucan recognition in fish suggests a key role for the C-type lectin pathway

J Petit, EC Bailey, RT Wheeler… - Frontiers in …, 2019 - frontiersin.org
Immune-modulatory effects of β-glucans are generally considered beneficial to fish health.
Despite the frequent application of β-glucans in aquaculture practice, the exact receptors …

Maintenance of homeostasis in the aging hypothalamus: the central and peripheral roles of succinate

TT Chen, EI Maevsky, ML Uchitel - Frontiers in endocrinology, 2015 - frontiersin.org
Aging is the phenotype resulting from accumulation of genetic, cellular, and molecular
damages. Many factors have been identified as either the cause or consequence of age …

In vitro effect of visfatin on endocrine functions of the porcine corpus luteum

E Mlyczyńska, E Rytelewska, E Zaobidna… - Scientific Reports, 2024 - nature.com
Previously, we demonstrated the expression of visfatin in porcine reproductive tissues and
its effect on pituitary endocrinology. The objective of this study was to examine the visfatin …

A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity

S Mohammad, RT Patel, J Bruno… - … and cellular biology, 2014 - Am Soc Microbiol
Glucose-dependent insulinotropic polypeptide (GIP), an incretin hormone secreted from
gastrointestinal K cells in response to food intake, has an important role in the control of …

Interaction of 5-HTTLPR and a variation on the oxytocin receptor gene influences negative emotionality

C Montag, CJ Fiebach, P Kirsch, M Reuter - Biological psychiatry, 2011 - Elsevier
BACKGROUND:: Pharmacological studies indicate a functional interaction between the
serotonergic and oxytocinergic system. METHODS:: This study tested for an interaction of …

Combinatorial guidance by CCR7 ligands for T lymphocytes migration in co-existing chemokine fields

S Nandagopal, D Wu, F Lin - PloS one, 2011 - journals.plos.org
Chemokines mediate the trafficking and positioning of lymphocytes in lymphoid tissues that
is crucial for immune surveillance and immune responses. In particular, a CCR7 ligand …