Membrane systems play an essential role in the production of all biopharmaceuticals. This
includes initial clarification of cell culture fluid by both depth filtration and tangential flow …

Purpose There is a growing interest in continuous biopharmaceutical processing due to the
advantages of small footprint, increased productivity, consistent product quality, high …

Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Continuous production delivers higher productivity and better quality than traditional batch-
wise approaches. It intensifies production lowering capital cost and enables better control …

Control of single pass tangential flow ultrafiltration is crucial for continuous manufacturing of
monoclonal antibodies. We propose a strategy to control the output concentration of a …

The biopharmaceutical industry has an ongoing interest in improving manufacturing
efficiency and productivity while at the same time reducing manufacturing costs by …

Single-pass tangential flow filtration (SPTFF) is a promising and increasingly important tool
for continuous biomanufacturing and intensified bioprocessing. SPTFF operates at high …

In this study the Single-Pass-Tangential-Flow-Filtration (SPTFF) concept for continuous
ultrafiltration in bioprocessing is investigated. Based on a previously validated physico …

The need to intensify downstream processing of monoclonal antibodies to complement the
advances in upstream productivity has led to increased attention toward implementing …

Over the last several years, continuous manufacturing of pharmaceuticals has evolved from
bulk APIs and solid oral dosages into the more complex realm of biologics. The …