Pyrimidine and fused pyrimidine derivatives as promising protein kinase inhibitors for cancer treatment
KRA Abdellatif, RB Bakr - Medicinal Chemistry Research, 2021 - Springer
Pyrimidine ring and its fused derivatives including pyrazolo [3, 4-d] pyrimidine, pyrido [2, 3-d]
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …
Recent updates on thienopyrimidine derivatives as anticancer agents
Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds.
They are important and widely represented in medicinal chemistry as they are structural …
They are important and widely represented in medicinal chemistry as they are structural …
Design, synthesis and anticancer evaluation of thieno [2, 3-d] pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers
Deregulation of many kinases is directly linked to cancer development and the tyrosine
kinase family is one of the most important targets in current cancer therapy regimens. In this …
kinase family is one of the most important targets in current cancer therapy regimens. In this …
Click chemistry based synthesis, cytotoxic activity and molecular docking of novel triazole-thienopyrimidine hybrid glycosides targeting EGFR
RR Khattab, AK Alshamari, AA Hassan… - Journal of enzyme …, 2021 - Taylor & Francis
In the current study, new thienopyrimidine conjugates bearing 1, 2, 3-triazole core and
different sugar moieties have been designed and synthesized by Cu (I)-catalysed click …
different sugar moieties have been designed and synthesized by Cu (I)-catalysed click …
Discovery of new VEGFR-2 inhibitors and apoptosis inducer-based thieno[2,3-d]pyrimidine
Background: VEGFR-2 is a key regulator of cancer cell proliferation, migration and
angiogenesis. Aim: Development of thieno [2, 3-d] pyrimidine derivatives as potential anti …
angiogenesis. Aim: Development of thieno [2, 3-d] pyrimidine derivatives as potential anti …
Synthesis and anti-microbial studies of new series of 1, 2, 3, 4-tetrazole integrated thieno [2, 3-d] pyrimidine derivatives
B Nagaraju, M Rajeswari, T Mounika, G Rajitha… - Journal of Molecular …, 2024 - Elsevier
The present study describes synthesis of a novel series of 1, 2, 3, 4-tetrazole integrated
thieno [2, 3-d]-pyrimidine hybrid 11a-l. Further, in vitro anti-microbial activities of the …
thieno [2, 3-d]-pyrimidine hybrid 11a-l. Further, in vitro anti-microbial activities of the …
Synthesis and in vitro antitumor evaluation of some new thiophenes and thieno [2, 3-d] pyrimidine derivatives
MM Fouad, ER El-Bendary, IA Shehata… - Bioorganic …, 2018 - Elsevier
Abstract New thiophene (2–13) and thienopyrimidine (15–27) derivatives have been
synthesized. Twenty three compounds were screened against five cell lines namely; …
synthesized. Twenty three compounds were screened against five cell lines namely; …
Synthesis, Anticancer Assessment, and Molecular Docking of Novel Chalcone‐Thienopyrimidine Derivatives in HepG2 and MCF‐7 Cell Lines
GM Safwat, KMA Hassanin… - Oxidative medicine …, 2021 - Wiley Online Library
Heterocycles containing thienopyrimidine moieties have attracted attention due to their
interesting biological and pharmacological activities. In this research article, we reported the …
interesting biological and pharmacological activities. In this research article, we reported the …
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein
I Al-Ramahi, SSP Giridharan, YC Chen, S Patnaik… - elife, 2017 - elifesciences.org
The discovery of the causative gene for Huntington's disease (HD) has promoted numerous
efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and …
efforts to uncover cellular pathways that lower levels of mutant huntingtin protein (mHtt) and …
Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors
A group of EGFR inhibitors derived from thieno [2, 3-d] pyrimidine nucleus was designed,
synthesised, and examined as anti-proliferative lead compounds. MCF-7 and A549 cell lines …
synthesised, and examined as anti-proliferative lead compounds. MCF-7 and A549 cell lines …