Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …

Gut microbiota in interaction with intestinal host tissues influences many brain functions and
microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric …

To assess the consistency of biological rhythms across studies, 57 public mouse liver tissue
timeseries totaling 1096 RNA-seq samples were obtained and analyzed. Only the control …

Background and Aims Characterization of cell specific transcriptional responses to
hepatotoxicants is lost in the averages of bulk RNA-sequencing (RNA-seq). Single …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

There is a growing awareness that the large number of environmental pollutants we are
exposed to on a daily basis are causing major health problems. Compared to traditional …

The gut microbiome plays a critical role in regulating host immunity and can no longer be
regarded as a bystander in human health and disease. In recent years, circadian (24 h) …

Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) dose-dependently induces the
development of hepatic fat accumulation and inflammation with fibrosis in mice initially in the …

During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has
emerged as a master activator of drug-and xenobiotic-metabolizing enzymes and …