Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease and
clinically manifests with cognitive decline and behavioral disabilities. Over the past years …

Inflammasome contributes to the pathogenesis of various inflammatory diseases, but the
epigenetic mechanism controlling its activation remains elusive. Here, we found that the …

Microglia are widely distributed in the central nervous system (CNS), where they aid in the
maintenance of neuronal function and perform key auxiliary roles in phagocytosis, neural …

Cluster of differentiation 36 (CD36) belongs to the B2 receptors of the scavenger receptor
class B family, which is comprised of single-chain secondary transmembrane glycoproteins …

Pellino1 (Peli1) is a highly conserved E3 Ub ligase that exerts its biological functions by
mediating target protein ubiquitination. Extensive evidence has demonstrated the crucial …

Despite annual increases in the incidence and prevalence of neurodegenerative diseases,
there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases …

Background Mitochondrial autophagy, the elimination of damaged mitochondria through
autophagy, contributes to neuron survival in cerebral ischemia. Long non-coding RNAs …

E3 ligases, essential components of the ubiquitin-proteasome-mediated protein degradation
system, play a critical role in cellular regulation. By covalently attaching ubiquitin (Ub) …

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease
affecting motor neurons and characterized by microglia-mediated neurotoxic inflammation …