Doxorubicin or Adriamycin, is one of the most widely used chemotherapeutic drug for
treating a myriad of cancers. It induces cell death through multiple intracellular targets …

Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases
family, of which main function is to mediate bone resorption. Currently, CatK is among the …

The clinical application of doxorubicin (DOX) for cancer treatment is limited due to its
cardiotoxicity. However, the basic pathophysiological molecular mechanisms underlying …

Doxorubicin (DOX) is one of the most effective antineoplastic drugs. However, its clinical
application has been greatly limited due to the development of cardiotoxicity with DOX …

Aims This study was aimed to investigate the role of GSDME-mediated pyroptosis in cardiac
injury induced by Doxorubicin (DOX), and to evaluate the role of BH3-only protein Bcl …

Doxorubicin is a valuable antineoplastic drug although its clinical use is greatly hindered by
its severe cardiotoxicity with dismal target therapy available. Luteolin is a natural product …

Purpose It has been supposed that cardiac toxicity of doxorubicin is due to its production of
free radicals and inflammatory cytokines. Dapsone, an antibiotic drug which is the principal …

Doxorubicin (DOX) is a widely used and potent anticancer agent, but DOX dose-
dependently induced cardiotoxicity greatly limits its use in clinic. Pterostilbene, a natural …

This study evaluated the cardioprotective properties of Boesenbergia rotunda extract (BrE)
against doxorubicin (DOX) induced cardiotoxicity. Rats received oral gavage of BrE for 28 …

Backgrounds: Salsolinol (SAL), a plant-based isoquinoline alkaloid, was initially isolated
from Aconiti Lateralis Radix Praeparata (ALRP) and identified as the active cardiotonic …