In a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been
developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) …

Detection of minimal residual disease (MRD) has prognostic value in many hematologic
malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia, chronic …

Background Sensitive techniques for detection of minimal residual disease (MRD) at
degrees of one leukaemic cell per 10 3–10 6 cells (10− 3–10− 6) during follow-up of …

Background and Methods The implications of the detection of residual disease after
treatment of acute lymphoblastic leukemia (ALL) are unclear. We conducted a prospective …

Assessment of minimal residual disease (MRD) has acquired a prominent position in
European treatment protocols for patients with acute lymphoblastic leukemia (ALL), on the …

The childhood leukemias are a study in contrasts. Acute lymphoblastic leukemia (ALL) is
diagnosed in approximately 2000 children in the United States each year, whereas acute …

Background The clinical significance of submicroscopic levels of leukaemic cells in bone-
marrow aspirates from children with acute lymphoblastic leukaemia (ALL) remains …

Christophe Pannetier, Jos Even and Philippe Kourilsky lmproved polymerase chailr reaction
(RX)-based methods now permit a mare in-depth analysis of the repertoire of T cells …

Abstract Analysis of minimal residual disease (MRD) can predict outcome in acute
lymphoblastic leukemia (ALL). A large prospective study in childhood ALL has shown that …

The detection of circulating tumor cells and micrometastases may have important prognostic
and therapeutic implications. Because their numbers can be very small, these tumor cells …