Inorganic polyphosphates (polyP) consist of linear chains of orthophosphate residues,
linked by high-energy phosphoanhydride bonds. They are evolutionarily old biopolymers …

Recent work has shown that acidocalcisomes, which are electron-dense acidic organelles
rich in calcium and polyphosphate, are the only organelles that have been conserved during …

This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years,
including new information on the genomics, epigenomics and proteomics of T. gondii as well …

Apicomplexan parasites have complex life cycles, frequently split between different hosts
and reliant on rapid responses as the parasites react to changing environmental conditions …

Acidocalcisomes are acidic organelles containing calcium and a high concentration of
phosphorus in the form of pyrophosphate (PPi) and polyphosphate (poly P). Organelles with …

Invasion of host cells by Toxoplasma gondii is accompanied by secretion of parasite
proteins that occurs coincident with increases in intracellular calcium. The source of calcium …

Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of
congenital disease and infection in immunocompromised patients. Like most …

Apicomplexan parasites cause persistent mortality and morbidity worldwide through
diseases including malaria, toxoplasmosis, and cryptosporidiosis. Ca 2+ signaling pathways …

Acidocalcisomes are acidic calcium storage compartments described initially in
trypanosomatid and apicomplexan parasites. In this work, we describe organelles with …

Calcium transporters that mediate the removal of Ca2+ from the cytosol and into internal
stores provide a critical role in regulating Ca2+ signals following stimulus induction and in …