The inflammasome is a cytoplasmic multiprotein complex responsible for the activation of
inflammatory caspases (caspase-1,-4, and-5) in response to pathogen-and/or damage …

Infection with Mycobacterium tuberculosis (Mtb) leading to tuberculosis (TB) disease
continues to be a major global health challenge. Critical barriers, including but not limited to …

Tuberculosis (TB) remains a serious public health burden worldwide. TB is an infectious
disease caused by the Mycobacterium tuberculosis Complex. Innate immune response is …

Mycobacterium tuberculosis (Mtb) infection represents a global health problem and is
characterized by formation of granuloma with a necrotic center and a systemic inflammatory …

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder of
multifactorial etiopathology likely to involve the interactions between genetics and lifestyle …

Cytokine gene single nucleotide polymorphisms (SNPs) can influence cytokine levels, which
may be associated with tuberculosis (TB) susceptibility. There is evidence that interleukin 1B …

Significance: Thioredoxin interacting protein (TXNIP) is a member of the arrestin fold
superfamily with important cellular functions, including cellular transport, mitochondrial …

Innate immunity is a first line defense against Mycobacterium tuberculosis infection where
inflammasome activation and secretion of the pro-inflammatory cytokine IL-1beta, plays a …

Tuberculosis (TB) is still an important global threat and although the causing organism has
been discovered long ago, effective prevention strategies are lacking. Mycobacterium …

Pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a global public
health concern. Although inflammasome and the toll-like receptor 2 (TLR2) genes play an …