Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in
mammals and are responsible for the regulation of most physiological functions. Besides …

Bitter taste-sensing type 2 receptors (TAS2Rs or T2Rs), belonging to the subgroup of family
A G-protein coupled receptors (GPCRs), are of crucial importance in the perception of …

The parasitic helminth Trichinella spiralis, which poses a serious health risk to animals and
humans, can be found worldwide. Recent findings indicate that a rare type of gut epithelial …

Quorum-sensing molecules (QSMs) are secreted by bacteria to signal population density.
Upon reaching a critical concentration, QSMs induce transcriptional alterations in bacteria …

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

Human gut and food microbiomes interact during digestion. The outcome of these
interactions influences the taxonomical composition and functional capacity of the resident …

The pathogenic bacterium Streptococcus pneumoniae (S. pneumoniae) can invade the
cerebrospinal fluid (CSF) and cause meningitis with devastating consequences. Whether …

The human G-protein-coupled bitter taste receptor T2R38 has recently been demonstrated
to be expressed on peripheral blood neutrophils, monocytes and lymphocytes. To further …

Diabetes mellitus can be subdivided into several categories based on origin and clinical
characteristics. The most common forms of diabetes are type 1 (T1D), type 2 diabetes (T2D) …

Background Nasal mucosa–derived exosomes (NMDEs) harbor immunodefensive proteins
and are capable of rapid interepithelial protein transfer. Objectives We sought to determine …