MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression.
They have important roles during kidney development, homeostasis and disease. In …

The most classical view of the renin-angiotensin system (RAS) emphasizes its role as an
endocrine regulator of sodium balance and blood pressure. However, it has long become …

Activation of the renin–angiotensin–aldosterone system (RAAS) plays an important
pathophysiological role in hypertension. Increased mRNA levels of the angiotensinogen …

Abstract The Epithelial Na+ Channel, ENaC, comprised of 3 subunits (αβγ, or sometimes
δβγENaC), plays a critical role in regulating salt and fluid homeostasis in the body. It …

Mineralocorticoids trigger a profibrotic process in the kidney. In mouse cortical collecting
duct cells, the present study addressed two main questions: 1) what are microRNAs …

Inappropriately activation of renin-angiotensin-aldosterone system induced renal fibrosis is
characterized by partial epithelial-to-mesenchymal transition. Previously, we have indicated …

The final steps in the Renin‐Angiotensin‐Aldosterone signaling System (RAAS) involve
binding of the corticosteroid hormone, aldosterone to its mineralocorticoid receptor (MR) …

The epithelial sodium channel (ENaC) is the limiting entry point for Na+ reabsorption in the
distal kidney nephron and is regulated by numerous hormones, including the …

The mammalian metanephric kidney is composed of two epithelial components, the
collecting duct system and the nephron epithelium, that differentiate from two different …

Kidney stones have been a long-standing health issue, contributing to renal failure,
especially in co-morbid patients. There is an increasing interest in exploring natural …