During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Specific cells within the early mammalian embryo have the capacity to generate all somatic
lineages plus the germline. This property of pluripotency is confined to the epiblast, a …

After fertilization, maternal factors direct development and trigger zygotic genome activation
(ZGA) at the maternal-to-zygotic transition (MZT). In zebrafish, ZGA is required for …

Phenotypic variability in genetic disease is usually attributed to genetic background variation
or environmental influence. Here, we show that deletion of a single gene, Trim28 (Kap1 or …

Pluripotent epiblast (EPI) cells, present in the inner cell mass (ICM) of the mouse blastocyst,
are progenitors of both embryonic stem (ES) cells and the fetus. Discovering how …

During blastocyst formation, inner cell mass (ICM) cells differentiate into either epiblast (Epi)
or primitive endoderm (PrE) cells, labeled by Nanog and Gata6, respectively, and organized …

Activation of the FGF signaling pathway during preimplantation development of the mouse
embryo is known to be essential for differentiation of the inner cell mass and the formation of …

During preimplantation mouse development, the inner cell mass (ICM) differentiates into two
cell lineages—the epiblast and the primitive endoderm (PrE)—whose precursors are …

Pluripotency is established through genome-wide reprogramming during mammalian pre-
implantation development, resulting in the formation of the naive epiblast. Reprogramming …

In embryonic stem (ES) cells and in early mouse embryos, the transcription factor Oct4 is an
essential regulator of pluripotency. Oct4 transcriptional targets have been described in ES …