Establishing clear relationships between in vitro and in vivo data for inhaled drug products is
an important goal. In vitro aerodynamic particle size distributions (APSDs) are expected to …

Fine particle fraction (FPF) is defined in general terms as the fraction or percentage of the
drug mass contained in an aerosol cloud that may be small enough to enter the lungs and …

Purpose The aims of the study are to analyze the influence of air flow on the overall
performance of a dry powder inhaler (Aerolizer®) and to provide an initial quantification of …

Conventional in vitro tests to assess the aerodynamic particle size distribution (APSD) from
inhaler devices use simple right-angle inlets (“mouth-throats”, MTs) to cascade impactors …

In vitro polydisperse aerosol deposition in three mouth–throat models, namely, the USP
(United States Pharmacopeia) mouth–throat (induction port), idealized mouth–throat, and …

Particle deposition in the human mouth-throat is an important factor in evaluating efficiency
of drug delivered by inhalation devices, such as pMDIs or DPIs. Current USP standard …

A unique reference and training aid that meets the essential needs of every drug metabolism
department or drug metabolism research team, this book provides insight into the use and …

Medication for the treatment of asthma and chronic obstructive pulmonary disease should be
given locally by inhalation. There is, however, no such thing as an ideal inhaler, or …

Three-dimensional (3D) radionuclide imaging provides detailed information on the
distribution of inhaled aerosol material within the body. Analysis of the data can provide …

Interest in bioequivalence (BE) of inhaled drugs derives largely from the desire to offer
generic substitutes to successful drug products. The complexity of aerosol dosage forms …