Cognitive dysfunction is common in Parkinson's disease (PD) and predicts poor clinical
outcomes. It is associated primarily with pathologic involvement of basal forebrain …

The diagnosis and treatment of urinary tract infections (UTIs) remain challenging due to the
lack of convenient assessment techniques and to the resistance to conventional …

Anticholinergics have been used in the treatment of overactive bladder (OAB), but their use
is limited by poor tolerability and anticholinergic-related side effects. Increasingly, providers …

α1-Adrenergic receptors (ARs) are members of the G-Protein Coupled Receptor superfamily
and with other related receptors (β and α2), they are involved in regulating the sympathetic …

Abstract Introduction We examined whether German claims data are suitable for dementia
risk prediction, how machine learning (ML) compares to classical regression, and what the …

Lower urinary tract symptoms (LUTS) are common among elderly people, with significant
effects on individuals, caregivers, and the wider health care system. As the elderly …

Background An association between adrenergic alpha-1 receptor antagonists and delirium
has been suggested, but the details are unclear. Aim This study investigated the association …

Prediction of high-risk events amongst patients with mental disorders is critical for
personalized interventions. We developed DeepBiomarker2 by leveraging deep learning …

Tamsulosin is an α 1-adrenoceptor antagonist used to treat benign prostatic hyperplasia.
This drug exhibits high affinity for α 1A-and α 1D-adrenoceptor subtypes, which are also …

Background Neurogenic detrusor overactivity (NDO) can damage the upper urinary tract
leading to chronic renal impairment. Antimuscarinic therapy is used to improve urinary …