Mass‐spectrometry coupled to liquid chromatography is an indispensable tool in the field of
proteomics. In the last decades, more and more complex and diverse biochemical and …

Post-translational modifications (PTMs) are ubiquitous and key to regulating protein function.
Understanding the dynamics of individual PTMs and their biological roles requires robust …

It has been suggested that in mammalian cells histidine residues in proteins may become as
frequently phosphorylated as serine, threonine and tyrosine, and may play a key role in …

Protein N-phosphorylation plays a critical role in central metabolism and
two/multicomponent signaling of prokaryotes. However, the current enrichment methods for …

Methylation can occur on histidine, lysine and arginine residues in proteins and often serves
a regulatory function. Histidine methylation has recently attracted attention through the …

Protein histidine phosphorylation (pHis) is involved in molecular signaling networks in
bacteria, fungi, plants, and higher eukaryotes including mammals and is implicated in …

Anti-neutrophil cytoplasmic autoantibodies (ANCAs) are directed against lysosomal
components of neutrophils. ANCAs directed to proteinase 3 and myeloperoxidase (MPO) in …

Bacterial pathogens rely on a complex network of regulatory proteins to adapt to hostile and
nutrient-limiting host environments. The p hosphoenolpyruvate p hosphotransferase s ystem …

Abstract Phosphoglycerate mutase 1 (PGAM1) is a key node enzyme that diverts the
metabolic reactions from glycolysis into its shunts to support macromolecule biosynthesis for …

Phosphorylation is a posttranslational modification that can affect both housekeeping
functions and virulence characteristics in bacterial pathogens. In the Gram-positive …