Phytosterols: Potential metabolic modulators in neurodegenerative diseases
Phytosterols constitute a class of natural products that are an important component of diet
and have vast applications in foods, cosmetics, and herbal medicines. With many and …
and have vast applications in foods, cosmetics, and herbal medicines. With many and …
[HTML][HTML] Cataract: advances in surgery and whether surgery remains the only treatment in future
X Chen, J Xu, X Chen, K Yao - Advances in Ophthalmology Practice and …, 2021 - Elsevier
Background Cataract is the world's leading eye disease that causes blindness. The
prevalence of cataract aged 40 years and older is approximately 11.8%–18.8%. Currently …
prevalence of cataract aged 40 years and older is approximately 11.8%–18.8%. Currently …
Altered cholesterol homeostasis in Huntington's disease
Huntington's disease (HD) is an autosomal dominant genetic disorder caused by an
expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated …
expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated …
CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington's disease
R Kacher, A Lamazière, N Heck, V Kappes, C Mounier… - Brain, 2019 - academic.oup.com
Dysfunctions in brain cholesterol homeostasis have been extensively related to brain
disorders. The main pathway for brain cholesterol elimination is its hydroxylation into 24S …
disorders. The main pathway for brain cholesterol elimination is its hydroxylation into 24S …
Comprehensive Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Pleurospermum candollei: An Insight into Potential for Natural …
The purpose of this study was to find the biological propensities of the vegetable plant
Pleurospermum candollei by investigating its phytochemical profile and biological activities …
Pleurospermum candollei by investigating its phytochemical profile and biological activities …
Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6
L Qian, NA Scott, IM Capell-Hattam, EA Draper… - Journal of Lipid …, 2023 - ASBMB
Cholesterol biosynthesis is a highly regulated pathway, with over 20 enzymes controlled at
the transcriptional and posttranslational levels. While some enzymes remain stable …
the transcriptional and posttranslational levels. While some enzymes remain stable …
Association between oxidative stress and altered cholesterol metabolism in Alzheimer's disease patients
Background: Oxidative stress is the main feature of several diseases including Alzheimer's
disease (AD). The involvement of oxysterols derivates has been recently reported. Objective …
disease (AD). The involvement of oxysterols derivates has been recently reported. Objective …
Polyphenolic flavonoid (Myricetin) upregulated proteasomal degradation mechanisms: Eliminates neurodegenerative proteins aggregation
Major neurodegenerative disorders are characterized by the formation of misfolded proteins
aggregates inside or outside the neuronal cells. Previous studies suggest that aberrant …
aggregates inside or outside the neuronal cells. Previous studies suggest that aberrant …
SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes
G Birolini, G Verlengia, F Talpo, C Maniezzi, L Zentilin… - Brain, 2021 - academic.oup.com
Brain cholesterol is produced mainly by astrocytes and is important for neuronal function. Its
biosynthesis is severely reduced in mouse models of Huntington's disease. One possible …
biosynthesis is severely reduced in mouse models of Huntington's disease. One possible …
E3 ubiquitin ligases neurobiological mechanisms: development to degeneration
Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of
various aberrant proteins in specific brain regions leads to neurodegeneration and aging …
various aberrant proteins in specific brain regions leads to neurodegeneration and aging …