Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …

Basic and clinical studies demonstrate that depression is associated with reduced size of
brain regions that regulate mood and cognition, including the prefrontal cortex and the …

Every individual experiences stressful life events. In some cases acute or chronic stress
leads to depression and other psychiatric disorders, but most people are resilient to such …

Basic and clinical studies demonstrate that stress and depression are associated with
atrophy and loss of neurons and glia, which contribute to the decreased size and function of …

Much of the current understanding about the pathogenesis of altered mood, impaired
concentration and neurovegetative symptoms in major depression has come from animal …

Major depressive disorder (MDD) is the leading cause of disability worldwide. There is an
urgent need for objective biomarkers to diagnose this highly heterogeneous syndrome …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation
and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a …