Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

C Groth, X Hu, R Weber, V Fleming, P Altevogt… - British journal of …, 2019 - nature.com
Under steady-state conditions, bone marrow-derived immature myeloid cells (IMC)
differentiate into granulocytes, macrophages and dendritic cells (DCs). This differentiation is …

Myeloid-derived suppressor cells in the tumor microenvironment

M Dysthe, R Parihar - Tumor Microenvironment: Hematopoietic Cells–Part …, 2020 - Springer
Myeloid-derived suppressor cells (MDSCs) represent a heterogenous population of
immature myeloid cells capable of modulating immune responses. In the context of cancer …

Myeloid-derived suppressor cells: critical cells driving immune suppression in the tumor microenvironment

KH Parker, DW Beury, S Ostrand-Rosenberg - Advances in cancer …, 2015 - Elsevier
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that suppress innate and adaptive immunity. MDSCs are present in many …

Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren's syndrome by modulating the function of myeloid-derived suppressor cells

K Rui, Y Hong, Q Zhu, X Shi, F Xiao, H Fu… - Cellular & molecular …, 2021 - nature.com
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by progressive
inflammation and tissue damage in salivary glands and lacrimal glands. Our previous …

Advances in the immunopathogenesis of multiple sclerosis

SK Yadav, JE Mindur, K Ito… - Current opinion in …, 2015 - journals.lww.com
A better understanding of immune-mediated mechanisms in the pathogenesis of multiple
sclerosis and the contribution of environmental risk factors toward the development of …

Here, there, and everywhere: myeloid-derived suppressor cells in immunology

S Ostrand-Rosenberg, TJ Lamb… - The Journal of …, 2023 - journals.aai.org
Myeloid-derived suppressor cells (MDSCs) were initially identified in humans and mice with
cancer where they profoundly suppress T cell–and NK cell–mediated antitumor immunity …

Myeloid-derived suppressor cells: not only in tumor immunity

G Pawelec, CP Verschoor… - Frontiers in …, 2019 - frontiersin.org
Since the realization that immature myeloid cells are powerful modulators of the immune
response, many studies on “myeloid-derived suppressor cells”(MDSCs) have documented …

Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine

MM Yaseen, NM Abuharfeil, H Darmani… - Open …, 2020 - royalsocietypublishing.org
Chronic immune activation and inflammation are unwanted consequences of many
pathological conditions, since they could lead to tissue damage and immune exhaustion …

Cannabidiol attenuates experimental autoimmune encephalomyelitis model of multiple sclerosis through induction of myeloid-derived suppressor cells

DM Elliott, N Singh, M Nagarkatti… - Frontiers in …, 2018 - frontiersin.org
Multiple sclerosis (MS) is a chronic debilitating autoimmune disease without a cure. While
the use of marijuana cannabinoids for MS has recently been approved in some countries …

Resolution of inflammation during multiple sclerosis

F Ruiz, S Vigne, C Pot - Seminars in immunopathology, 2019 - Springer
Multiple sclerosis (MS) is a frequent autoimmune demyelinating disease of the central
nervous system (CNS). There are three clinical forms described: relapsing-remitting multiple …