[HTML][HTML] Lipocalin-2: Structure, function, distribution and role in metabolic disorders

S Al Jaberi, A Cohen, C D'Souza… - Biomedicine & …, 2021 - Elsevier
Abstract Lipocalin-2 (LCN-2) is a novel, 198 amino acid adipocytokine also referred to as
neutrophil gelatinase-associated lipocalin (NGAL). LCN-2 is a circulatory protein …

MMP9: a tough target for targeted therapy for cancer

K Augoff, A Hryniewicz-Jankowska, R Tabola, K Stach - Cancers, 2022 - mdpi.com
Simple Summary MMP9, due to its proteolytic activity, plays a key role in tumorigenesis by
regulating migration, epithelial-to-mesenchymal transition and survival of cancer cells …

Granulopoiesis and granules of human neutrophils

JB Cowland, N Borregaard - Immunological reviews, 2016 - Wiley Online Library
Granules are essential for the ability of neutrophils to fulfill their role in innate immunity.
Granule membranes contain proteins that react to environmental cues directing neutrophils …

The review of current knowledge on neutrophil gelatinase-associated lipocalin (NGAL)

K Romejko, M Markowska, S Niemczyk - International journal of molecular …, 2023 - mdpi.com
Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein that is secreted
mostly by immune cells such as neutrophils, macrophages, and dendritic cells. Its production …

Acute kidney injury: medical causes and pathogenesis

F Turgut, AS Awad, EM Abdel-Rahman - Journal of Clinical Medicine, 2023 - mdpi.com
Acute kidney injury (AKI) is a common clinical syndrome characterized by a sudden decline
in or loss of kidney function. AKI is not only associated with substantial morbidity and …

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade

J Vandooren, PE Van den Steen… - Critical reviews in …, 2013 - Taylor & Francis
Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

A Rodríguez, S Ezquerro… - American Journal …, 2015 - journals.physiology.org
Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Neutrophil gelatinase-associated lipocalin (NGAL) in kidney injury–A systematic review

V Marakala - Clinica chimica acta, 2022 - Elsevier
Abstract Background Neutrophil Gelatinase Associated Lipocalin (NGAL) is a secretory
protein of neutrophils that can be found both in plasma and urine. Previous works have …

Physiology and pathophysiology of matrix metalloproteases

T Klein, R Bischoff - Amino acids, 2011 - Springer
Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates
based on a conserved mechanism involving activation of an active site-bound water …

The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer

S Chakraborty, S Kaur, S Guha, SK Batra - Biochimica et Biophysica Acta …, 2012 - Elsevier
Neutrophil gelatinase associated lipocalin (NGAL), also known as oncogene 24p3,
uterocalin, siderocalin or lipocalin 2, is a 24kDa secreted glycoprotein originally purified …