The space of disse: the liver hub in health and disease

C Sanz-García, A Fernández-Iglesias, J Gracia-Sancho… - Livers, 2021 - mdpi.com
Since it was first described by the German anatomist and histologist, Joseph Hugo Vincenz
Disse, the structure and functions of the space of Disse, a thin perisinusoidal area between …

A review of effects of atorvastatin in cancer therapy

Z Shaghaghi, M Alvandi, S Farzipour, MR Dehbanpour… - Medical oncology, 2022 - Springer
Cancer is one of the most challenging diseases to manage. A sizeable number of
researches are done each year to find better diagnostic and therapeutic strategies. At the …

Liver cirrhosis: molecular mechanisms and therapeutic interventions

Z Dong, Y Wang, W Jin - MedComm, 2024 - Wiley Online Library
Liver cirrhosis is the end‐stage of chronic liver disease, characterized by inflammation,
necrosis, advanced fibrosis, and regenerative nodule formation. Long‐term inflammation …

Tussilagone inhibits osteoclastogenesis by modulating mitochondrial function and ROS production involved Nrf2 activation

X Feng, Z Liu, Y Su, H Lian, Y Gao, J Zhao, J Xu… - Biochemical …, 2023 - Elsevier
Abstract Reactive Oxygen Species (ROS) play an essential role in the pathogenesis of
osteoporosis mainly characterized by excessive osteoclasts (OCs) activity. OCs are rich in …

[HTML][HTML] Targeting foamy macrophages by manipulating ABCA1 expression to facilitate lesion healing in the injured spinal cord

X Wang, Z Cheng, W Tai, M Shi, M Ayazi, Y Liu… - Brain, Behavior, and …, 2024 - Elsevier
Spinal cord injury (SCI) triggers a complex cascade of events, including myelin loss,
neuronal damage, neuroinflammation, and the accumulation of damaged cells and debris at …

Therapeutic effect of exosomes derived from hepatocyte-growth-factor-overexpressing adipose mesenchymal stem cells on liver injury

L Yu, J Xue, Y Wu, H Zhou - Folia Histochemica et …, 2023 - journals.viamedica.pl
Adipose mesenchymal stem cell-derived exosomes (ADMSC-Exo) are a new strategy for the
treatment of liver injury. However, mesenchymal stem cells (MSCs) exert therapeutic effects …

Impact of atorvastatin on plasma and cardiac biomarkers of inflammation, oxidative stress, and fibrosis in a rat model of streptozotocin-induced diabetes

F Mayyas, T Al Gharram - Naunyn-Schmiedeberg's Archives of …, 2023 - Springer
Oxidative stress and fibrosis foster the development of cardiovascular disease (CVD) in
diabetes. Atorvastatin protects against cardiovascular diseases in diabetes patients …

Elucidating the mechanisms of hugan buzure granule in the treatment of liver fibrosis via network pharmacology

Y Zhu, M Qiao, J Yang, J Hu - … ‐Based Complementary and …, 2020 - Wiley Online Library
Objective. To holistically explore the latent active ingredients, targets, and related
mechanisms of Hugan buzure granule (HBG) in the treatment of liver fibrosis (LF) via …

Protective Effect of Atorvastatin on Benzopyrene-Induced Hepatorenal Toxicity: A Histopathological Study

A Karimpour, M Mirzaei, Z Rahmani… - … of Medical Sciences, 2022 - jmums.mazums.ac.ir
Background and purpose: Benzo [a] pyrene (BaP) is an environmental pollutant that has
genotoxic and carcinogenic effects. Atorvastatin (ATV), as a lipid-lowering drug, has …

[PDF][PDF] Protective Effect of Atorvastatin on Benzopyrene-Induced Hepatorenal Toxicity: A Histopathological Study

AK Malekshah, M Mirzaei, Z Rahmani, AE Mogaddam… - 2022 - jmums.mazums.ac.ir
Background and purpose: Benzo [a] pyrene (BaP) is an environmental pollutant that has
genotoxic and carcinogenic effects. Atorvastatin (ATV), as a lipid-lowering drug, has …