Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …

Branchio‐oto‐renal syndrome, a phenotype consisting of hearing loss, auricular
malformations, branchial arch remnants, and renal anomalies is now recognized as one of …

SIX1 interacts with EYA to form a bipartite transcription factor essential for mammalian
development. Loss of function of this complex causes branchio-oto-renal (BOR) syndrome …

Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder
characterized by the association of branchial arch defects, hearing loss, and renal …

Innate immunity is stimulated not only by viral or bacterial components, but also by non-
microbial danger signals (damage-associated molecular patterns). One of the damage …

Integration of multiple signaling pathways at the level of their transcriptional effectors
provides an important strategy for fine-tuning gene expression and ensuring a proper …

Many larval sponges possess pigment ring eyes that apparently mediate phototactic
swimming. Yet sponges are not known to possess nervous systems or opsin genes, so the …

Abstract Branchio‐oto‐renal (BOR) syndrome is an autosomal dominant disorder
characterized by branchiogenic malformation, hearing loss and renal anomalies. The …

Branchio‐oto‐renal syndrome (BOR) is an autosomal dominant disorder characterized by
the association of branchial and external ear malformations, hearing loss, and renal …

Single-nucleotide mutations in human SIX1 result in amino acid substitutions in either the
protein-protein interaction domain or the homeodomain, and cause∼ 4% of branchio-otic …