Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are
associated with multiple kidney abnormalities. Young patients with SCD have elevated …

Glomerular hyperfiltration (GHF) is a phenomenon that can occur in various clinical
conditions affecting the kidneys such as sickle cell disease, diabetes mellitus, autosomal …

Kidney function follows a 24-h rhythm subject to regulation by circadian genes including the
transcription factor Bmal1. A high-salt diet induces a phase shift in Bmal1 expression in the …

It is critical to characterize the natural history of albuminuria in patients with sickle cell
anemia (SCA); however, these data are currently lacking and affecting evidence-based …

A deeper pathophysiologic understanding of available mouse models of sickle cell disease
(SCD), such as the Townes model, will help improve preclinical studies. We evaluated …

Hyperglycemia can also induce the production of free radicals and the progression of
inflammatory reactions. The aim of this study is to explore the potential anti-oxidant and anti …

Sickle cell nephropathy (SCN) is a leading cause of morbidity and mortality in sickle cell
disease (SCD). Early intervention is crucial for mitigating its effects. However, current …

The root cause of sickle cell disease (SCD) has been known for nearly a century, however,
few therapies to treat the disease are available. Over several decades of work, with …

Chronic kidney disease (CKD) is a major contributor to morbidity and mortality in sickle cell
disease (SCD). Anemia, induced by chronic persistent hemolysis, is associated with the …

Glomerular hyperfiltration is common in young sickle cell anemia patients and precedes
development of overt kidney disease. In this multicenter pooled cohort, we characterized …