The spliceosome removes introns from messenger RNA precursors (pre-mRNA). Decades
of biochemistry and genetics combined with recent structural studies of the spliceosome …

High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

During exon ligation, the Saccharomyces cerevisiae spliceosome recognizes the 3′-splice
site (3′ SS) of precursor messenger RNA (pre-mRNA) through non–Watson-Crick pairing …

Background Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer
with limited therapeutic opportunities. Recently, splicing factors have gained attention as …

The regulatory mechanisms of anthocyanin biosynthesis have been well documented at the
transcriptional and translational levels. By contrast, how anthocyanin biosynthesis is …

Protein termini are determinants of protein stability. Proteins bearing degradation signals, or
degrons, at their amino‐or carboxyl‐termini are eliminated by the N‐or C‐degron pathways …

Researching depletions in homozygous genotypes for specific haplotypes among the large
cohorts of animals genotyped for genomic selection is a very efficient strategy to map …

Elevated DNA replication stress causes instability of the DNA replication fork and increased
DNA mutations, which underlies tumorigenesis. The DNA replication stress regulator …

Alternative splicing is a common but complex posttranscriptional regulatory process in
eukaryotes, through which multiple different transcripts are produced from a single pre …

Background Viviparity—live birth—is a complex and innovative mode of reproduction that
has evolved repeatedly across the vertebrate Tree of Life. Viviparous species exhibit …