Adaptive proton therapy

H Paganetti, P Botas, GC Sharp… - Physics in Medicine & …, 2021 - iopscience.iop.org
Radiation therapy treatments are typically planned based on a single image set, assuming
that the patient's anatomy and its position relative to the delivery system remains constant …

Status and innovations in pre-treatment CT imaging for proton therapy

P Wohlfahrt, C Richter - The British journal of radiology, 2020 - academic.oup.com
Pre-treatment CT imaging is a topic of growing importance in particle therapy. Improvements
in the accuracy of stopping-power prediction are demanded to allow for a dose conformality …

Experimental comparison of proton CT and dual energy x-ray CT for relative stopping power estimation in proton therapy

G Dedes, J Dickmann, K Niepel, P Wesp… - Physics in Medicine …, 2019 - iopscience.iop.org
Proton computed tomography (pCT) has been proposed as an alternative to x-ray computed
tomography (CT) for acquiring relative to water stopping power (RSP) maps used for proton …

Dual-and multi-energy CT for particle stopping-power estimation: current state, challenges and potential

M Yang, P Wohlfahrt, C Shen… - Physics in Medicine & …, 2023 - iopscience.iop.org
Range uncertainty has been a key factor preventing particle radiotherapy from reaching its
full physical potential. One of the main contributing sources is the uncertainty in estimating …

On the molecular relationship between Hounsfield Unit (HU), mass density, and electron density in computed tomography (CT)

A Sudhyadhom - PLoS One, 2020 - journals.plos.org
Accurate determination of physical/mass and electron densities are critical to accurate
spatial and dosimetric delivery of radiotherapy for photon and charged particles. In this …

Towards subpercentage uncertainty proton stopping‐power mapping via dual‐energy CT: Direct experimental validation and uncertainty analysis of a statistical …

M Medrano, R Liu, T Zhao, T Webb, DG Politte… - Medical …, 2022 - Wiley Online Library
Purpose To assess the potential of a joint dual‐energy computerized tomography (CT)
reconstruction process (statistical image reconstruction method built on a basis vector model …

Pre-clinical evaluation of dual-layer spectral computed tomography-based stopping power prediction for particle therapy planning at the Heidelberg Ion Beam Therapy …

FK Faller, S Mein, B Ackermann, J Debus… - Physics in Medicine …, 2020 - iopscience.iop.org
Accurate beam range prediction during clinical treatment planning is key to improve targeted
dose delivery in proton and heavy ion therapy. A substantial source of beam range …

A methodology for improved accuracy in stopping power estimation using MRI and CT

JE Scholey, D Chandramohan, T Naren, W Liu… - Medical …, 2021 - Wiley Online Library
Purpose Proton therapy is becoming an increasingly popular cancer treatment modality due
to the proton's physical advantage in that it deposits the majority of its energy at the distal …

Improved accuracy of relative electron density and proton stopping power ratio through CycleGAN machine learning

J Scholey, L Vinas, V Kearney, S Yom… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective. Kilovoltage computed tomography (kVCT) is the cornerstone of radiotherapy
treatment planning for delineating tissues and towards dose calculation. For the former …

[HTML][HTML] The influence of dual-energy computed tomography image noise in proton therapy treatment planning

T Näsmark, J Andersson - Physics and Imaging in Radiation Oncology, 2023 - Elsevier
Background and purpose In proton therapy, a 3.5% margin is often used to account for
proton range uncertainties, of which computed tomography (CT) image noise is assumed to …