Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein
degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice …

Alzheimer's disease (AD) is the most common type of dementia in the elderly population.
Three genes have been identified as responsible for the rare early-onset familial form of the …

Alzheimer's disease (AD) is caused by the cerebral deposition of β-amyloid (Aβ), a 38–43-
amino acid peptide derived by proteolytic cleavage of the amyloid precursor protein (APP) …

The identification of cathepsins in amyloid-β plaques revealed broad dysfunction of the
lysosomal system in Alzheimer's disease (AD). Coinciding with the discovery that proteolysis …

Microglia, the main phagocytes of the central nervous system (CNS), are involved in the
surveillance and maintenance of nervous tissue. During normal tissue homeostasis …

Objectives: Diagnostic tests able to reveal Alzheimer's disease (AD) in living patients before
cognitive ability is destroyed are urgently needed. Such tests must distinguish AD from other …

Polymorphic genes associated with Alzheimer's disease (see) delineate a clearly defined
pathway related to cerebral and peripheral cholesterol and lipoprotein homoeostasis. They …

Alzheimer's disease (AD), the most common cause of dementia, causes irreversible memory
loss and cognitive deficits. Current AD drugs do not significantly improve cognitive function …

The majority of mutations causing familial Alzheimer's disease (fAD) have been found in the
gene PRESENILIN1 (PSEN1) with additional mutations in the related gene PRESENILIN2 …