Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research

J Hodon, L Borkova, J Pokorny, A Kazakova… - European journal of …, 2019 - Elsevier
Triterpenoids are natural products from plants and many other organisms that have various
biological activities, such as antitumor, antiviral, antimicrobial, and protective activities. This …

Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatilla chinensis

Y Li, M Zou, Q Han, L Deng, RM Weinshilboum - Pharmacological research, 2020 - Elsevier
Abstract Pulsatilla Decoction (Bai-Tou-Weng-Tang) has been used medically in China for
thousands of years for the treatment of diseases caused by bacteria. In recent decades …

Recent developments in the functionalization of betulinic acid and its natural analogues: a route to new bioactive compounds

JLC Sousa, CSR Freire, AJD Silvestre, AMS Silva - Molecules, 2019 - mdpi.com
Betulinic acid (BA) and its natural analogues betulin (BN), betulonic (BoA), and 23-
hydroxybetulinic (HBA) acids are lupane-type pentacyclic triterpenoids. They are present in …

Natural-product-based fluorescent probes: recent advances and applications

DB Sung, JS Lee - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Fluorescent probes are attractive tools for biology, drug discovery, disease diagnosis, and
environmental analysis. In bioimaging, these easy-to-operate and inexpensive probes can …

Discovery of fluorescent coumarin-benzo [b] thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors

G Cai, W Yu, D Song, W Zhang, J Guo, J Zhu… - European journal of …, 2019 - Elsevier
STAT3 has been extensively studied as a potential antitumor target. Though studies on
regulating STAT3 mainly focus on the inhibition of STAT3 phosphorylation at Tyr705 …

Triterpenoids as reactive oxygen species modulators of cell fate

T Ling, L Boyd, F Rivas - Chemical Research in Toxicology, 2022 - ACS Publications
The triterpenoid natural products have played an important role in understanding
mechanistic models of human diseases. These natural products are diverse, but many have …

Treatment of Parkinson's disease in Zebrafish model with a berberine derivative capable of crossing blood brain barrier, targeting mitochondria, and convenient for …

L Wang, W Sheng, Z Tan, Q Ren, R Wang… - … and Physiology Part C …, 2021 - Elsevier
Berberine is a famous alkaloid extracted from Berberis plants and has been widely used as
medications and functional food additives. Recent studies reveal that berberine exhibits …

Synthesis and biological activity of triterpene–coumarin conjugates

K Vega-Granados, M Medina-O'Donnell… - Journal of Natural …, 2021 - ACS Publications
A set of 12 maslinic acid–coumarin conjugates was synthesized, with 9 being maslinic acid–
diamine–coumarin conjugates at the C-28 carboxylic acid group of triterpene acid and the …

Design, Synthesis, and Biological Evaluation of Esculetin–Furoxan–DEAC Ternary Hybrids for Anti-Triple Negative Breast Cancer

M Wen, J Sun, M Yang, X Zhang, Y Wang… - Journal of Medicinal …, 2023 - ACS Publications
Twelve new hybrid compounds of Esculetin with nitric oxide (NO) donors and/or
mitochondrial targeting groups were designed, synthesized, and evaluated for their anti …

The application of nitrogen heterocycles in mitochondrial-targeting fluorescent markers with neutral skeletons

Y Wang, B Xu, R Sun, YJ Xu, JF Ge - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Four different neutral fluorescent markers containing nitrogen heterocycles (quinoxaline, 1H-
pyrazolo [3, 4-b] pyridine, 1H-indazole and 1H-pyrrolo [2, 3-b] pyridine) as targeting groups …