The development of neuronal circuitry required for cognition, complex motor behaviors, and
sensory integration requires myelination. The role of glial cells such as astrocytes and …

Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal
and molecular processes. Technological innovations now allow for parallel investigation of …

The integrity of myelinated axons relies on homeostatic support from oligodendrocytes
(OLs). To determine how OLs detect axonal spiking and how rapid axon–OL metabolic …

Myelin is required for rapid nerve signaling and is emerging as a key driver of CNS plasticity
and disease. How myelin is built and remodeled remains a fundamental question of …

Myelin is essential for rapid nerve signaling and is increasingly found to play important roles
in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as …

Peripheral nerves and Schwann cells have to sustain constant mechanical constraints,
caused by developmental growth as well as stretches associated with movements of the …

Oligodendrocyte precursor cells (OPCs) generate oligodendrocytes, contributing to
myelination and myelin repair. OPCs contact axons and respond to neuronal activity, but …

Myelin is a lipid-rich membrane that wraps around axons and facilitates rapid action
potential propagation. In the brain, myelin is synthesized and maintained by …

Central nervous system myelination increases action potential conduction velocity.
However, it is unclear how myelination is coordinated to ensure the temporally precise …

Oligodendrocytes (ODCs) are myelinating cells of the central nervous system (CNS)
supporting neuronal survival. Oxidants and mitochondrial dysfunction have been suggested …