To adequately prepare for potential hazards caused by emerging and reemerging infectious
diseases, the WHO has issued a list of high-priority pathogens that are likely to cause future …

The recent Zika virus (ZIKV) epidemic in the Americas and the Caribbean revealed a new
deadly strain of the mosquito-borne virus, which has never been associated with previous …

Abstract Zika virus (ZIKV; Flaviviridae, Flavivirus) was discovered in 1947 in Uganda, Africa,
from the serum of a sentinel Rhesus monkey (Macaca mulatta). It is an enveloped, positive …

Objectives Type 2 diabetes mellitus (T2DM) and hypertension (HTN) are common
comorbidities, and known to affect the brain. However, little is known about the effects of the …

Mosquito-borne and sexual transmission of Zika virus (ZIKV), a TORCH pathogen, recently
initiated a series of large epidemics throughout the Tropics. Animal models are necessary to …

Background Commonly used opioids, such as morphine have been implicated in
augmented SIV/HIV persistence within the central nervous system (CNS). However, the …

The consequences of simultaneous infection with Zika (ZIKV) and Dengue (DENV) viruses
are poorly understood. Here we show that rhesus macaques experimentally coinfected …

The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts
DNA repair pathways, modulates viral immune sensing, and induces cell-cycle arrest in cell …

Cytotoxic CD4+ T cells (CD4+ CTLs) limit HIV pathogenesis, as evidenced in elite
controllers (a subset of individuals who suppress the virus without the need for therapy) …

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) and is primarily transmitted by
Aedes species mosquitoes; however, ZIKV can also be sexually transmitted. During the …