Cervical cancer incidence is tightly linked to HPV infection, and particularly virus types 16
and 18 cause the majority of cases presenting with pre-cancerous stages of cervical …

During protein evolution, some amino acid substitutions modulate protein function
(“tuneability”). In most proteins, the tuneable range is wide and can be sampled by a set of …

Intrinsically disordered proteins (IDPs) and proteins with long intrinsically disordered protein
regions (IDPRs) lack ordered structure but are involved in a multitude of biological …

DNA binding by the ETS transcriptional repressor ETV6 (or TEL) is auto-inhibited~ 50-fold
due to an α-helix that sterically blocks its ETS domain binding interface. Using NMR …

Transcription factor (TF)-based biosensors are expected to serve as powerful tools for the
high-throughput screening of biocatalytic systems; however, most of them respond to ligands …

We discovered a new class of artificial peptidic transfection vectors based on an artificial
anion‐binding motif, the guanidiniocarbonylpyrrole (GCP) cation. This new type of vector is …

Iron-inducible transcription of the ap65-1 gene in Trichomonas vaginalis involves at least
three Myb-like transcriptional factors (tv Myb1, tv Myb2 and tv Myb3) that differentially bind to …

Background The identification of the mechanisms of adaptation of protein structures to
extreme environmental conditions is a challenging task of structural biology. We performed …

Sequence-specific binding of proteins to their DNA targets involves a complex spectrum of
processes that often induce DNA conformational variation in the bound complex. The forces …

NMR spectroscopy is the most versatile technique for the investigation of structural and
dynamic aspects of biological molecules and their interactions in solution. In addition, recent …