Vertebral anomalies causing congenital scoliosis are classified on the basis of failures of
formation, segmentation, or both. The natural history depends on the type of anomaly and …

Model organisms like the mouse are important tools to learn more about gene function in
man. Within the last 20years many mutant mouse lines have been generated by different …

Scoliosis is a complex genetic disorder of the musculoskeletal system, characterized by
three-dimensional rotation of the spine. Curvatures caused by malformed vertebrae …

Abstract 2, 3, 7, 8 Tetrachlorodibenzo-p-dioxin (TCDD) has been associated with many
disease states in humans. A rising concern is that exposure early in life can lead to adult …

Background: Congenital scoliosis is a failure of vertebral formation, segmentation, or a
combination of the 2 arising from abnormal vertebral development during weeks 4 to 6 of …

With the recent advance in genome-wide association studies (GWAS), disease-associated
single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) have been …

Vertebral malformations contribute substantially to the pathophysiology of kyphosis and
scoliosis, common health problems associated with back and neck pain, disability, cosmetic …

Due to the sporadic occurrence of congenital vertebral malformations, traditional linkage
approaches to identify genes associated with human vertebral development are not …

Exposure of gestating female rats to the anti-androgenic endocrine disruptor vinclozolin has
been shown to induce transgenerational adult onset disease phenotypes. The current study …

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