Lymphangioleiomyomatosis (LAM) is a rare progressive lung disease of women. LAM is
caused by mutations in the tuberous sclerosis genes, resulting in activation of the mTOR …

Lymphangioleiomyomatosis (LAM) is a multisystem disease of women, characterized by
proliferation of abnormal smooth muscle-like LAM cells, leading to the formation of lung …

METHODS The purpose of the LAM Task Force was to produce evidence based, consensus
guidelines for the diagnosis, assessment and treatment of patients with LAM. The two …

Environmental factors are important regulators of cell growth and proliferation. Mechanistic
target of rapamycin (mTOR) is a central kinase that maintains cellular homeostasis in …

Extracellular matrix metalloproteinases (MMPs) are a group of proteins that activate
substrates by enzymatic cleavage and, on the basis of their activities, have been …

Rationale: The relevance of hormones in idiopathic pulmonary fibrosis (IPF), a
predominantly male lung disease, is unknown. Objectives: To determine whether the ER …

Cell behavior is highly dependent upon microenvironment. Thus, to identify drugs targeting
metastatic cancer, screens need to be performed in tissue mimetic substrates that allow cell …

The observation that pulmonary inflammatory lesions and bleomycin (BLM)-induced
pulmonary fibrosis spontaneously resolve in young mice, whereas remaining irreversible in …

Lymphangioleiomyomatosis (LAM) is a rare disease characterized by proliferation of
abnormal smooth-muscle cells in the lungs, leading to functional loss and sometimes lung …

Lymphangioleiomyomatosis (LAM) is a devastating rare lung disease affecting primarily
childbearing age women in which tumors consisting of abnormal smooth-muscle-like cells …