Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Liver fibrosis due to viral or metabolic chronic liver diseases is a major challenge of global
health. Correlating with liver disease progression, fibrosis is a key factor for liver disease …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Chronic liver injury of many etiologies produces liver fibrosis and may eventually lead to the
formation of cirrhosis. Fibrosis is part of a dynamic process associated with the continuous …

The origin of fibrogenic cells in liver fibrosis remains controversial. We assessed the
emerging concept that hepatocytes contribute to production of extracellular matrix (ECM) in …

Liver damage leads to an inflammatory response and to the activation and proliferation of
mesenchymal cell populations within the liver which remodel the extracellular matrix as part …

Portal fibroblasts are an important yet often overlooked nonparenchymal cell population in
the liver. They are distinct from hepatic stellate cells, yet like stellate cells differentiate in the …

Myofibroblasts derived from portal fibroblasts are important fibrogenic cells in the early
stages of biliary fibrosis. In contrast to hepatic stellate cells, portal fibroblasts have not been …

Significance: The extracellular matrix (ECM) is a dynamic microenvironment that undergoes
continuous remodeling, particularly during injury and wound healing. Chronic liver injury of …