Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …

Tacrine is a drug used in the treatment of Alzheimer's disease as a cognitive enhancer and
inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has …

Acetylcholinesterase is an important biochemical enzyme in that it controls acetylcholine-
mediated neuronal transmission in the central nervous system, contains a unique structure …

The six and seven hydrocycle membered disilylanilino acridine (tacrine) analogues (9–11)
were synthesized by one-pot procedures. The structures of novel silyl tacrine derivatives …

Quinoline analogs are an important class of N-based heterocyclic compounds, which have
received extensive attention because of their use in medicinal chemistry and organic …

Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by
progressive memory loss, declining language skills and other cognitive disorders. AD has …

The present work describes the catalytic activity of Cu-MOF for the one-pot synthesis of
tacrine derivatives via a four-component reaction of 2-hydroxynaphthalene-1, 4-dione …

Alzheimer's Disease (AD), affecting a large population worldwide, is characterized by the old
population's loss of memory and learning ability. Cholinergic deficiency is associated with …

Cholinesterase and monoamine oxidase are potential targets for the therapy of Alzheimer's
disease. A series of novel AP2238-clorgiline hybrids as multi-target agents were designed …

A series of novel tacrine-phenolic acid dihybrids and tacrine-phenolic acid-ligustrazine
trihybrids were synthesized, characterized and screened as novel potential anti-Alzheimer …