The vagus nerve represents the main component of the parasympathetic nervous system,
which oversees a vast array of crucial bodily functions, including control of mood, immune …

Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …

Vagal nerve stimulation (VNS) is an approved treatment for epilepsy and is currently under
investigation as a therapy for other disorders, including depression, anxiety and Alzheimer's …

Treatment-resistant depression (TRD) is a major public health problem in terms of its
prevalence and in terms of individual suffering and cost to society. Best estimates indicate …

The vagus nerve, the great wanderer, is involved in numerous processes throughout the
body and vagus nerve stimulation (VNS) has the potential to modulate many of these …

BACKGROUND: Vagus nerve stimulation (VNS) alters both concentrations of
neurotransmitters or their metabolites and functional activity of central nervous system …

Currently available therapeutic interventions for treatment-resistant depression, including
switch, combination, and augmentation strategies, are less than ideal. Observations of mood …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Vagus nerve stimulation (VNS) is an antiepileptic treatment, which has recently shown
promise as an antidepressant. Yet, its antidepressant mechanisms of action are unknown …

Background: Epilepsy is a chronic brain disease that is caused by various factors and
characterized by recurrent, episodic and temporary central nervous system dysfunction …