[图书][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

[HTML][HTML] DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression

K Xu, S Sun, M Yan, J Cui, Y Yang, W Li… - Frontiers in …, 2022 - frontiersin.org
DEAD-box (DDX) 5 and DDX17, which belong to the DEAD-box RNA helicase family, are
nuclear and cytoplasmic shuttle proteins. These proteins are expressed in most tissues and …

[HTML][HTML] Long noncoding RNA LINC00239 inhibits ferroptosis in colorectal cancer by binding to Keap1 to stabilize Nrf2

Y Han, X Gao, N Wu, Y Jin, H Zhou, W Wang… - Cell death & …, 2022 - nature.com
Ferroptosis, a novel regulated cell death induced by iron-dependent lipid peroxidation, plays
an important role in tumor development and drug resistance. Long noncoding RNAs …

GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail

L Chen, Q Cai, R Yang, H Wang… - Proceedings of the …, 2023 - National Acad Sciences
Ferroptosis is an iron-dependent oxidative, nonapoptotic form of regulated cell death caused
by the destruction of redox homeostasis. Recent studies have uncovered complex cellular …

[HTML][HTML] Long noncoding RNAs: fine-tuners hidden in the cancer signaling network

S Zhao, X Zhang, S Chen, S Zhang - Cell death discovery, 2021 - nature.com
With the development of sequencing technology, a large number of long non-coding RNAs
(lncRNAs) have been identified in addition to coding genes. LncRNAs, originally considered …

[HTML][HTML] Non-canonical functions of spliceosome components in cancer progression

OM Ivanova, KS Anufrieva, AN Kazakova… - Cell Death & …, 2023 - nature.com
Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is
associated with altered expression, localization, and mutations of the components of the …

Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist

Y Guo, J Yang, Y He, H Zhou, Y Wang, Z Ding, B Jin… - Phytomedicine, 2022 - Elsevier
Background Pyroptosis is a pro-inflammatory cell death characterized by the formation of
inflammasomes. Abnormal inflammation in brain microvascular endothelial cells (BMECs) …

TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation

M Fischer, R Schwarz, K Riege, JA DeCaprio… - NAR …, 2022 - academic.oup.com
In recent years, our web-atlas at www. TargetGeneReg. org has enabled many researchers
to uncover new biological insights and to identify novel regulatory mechanisms that affect …

AggMapNet: enhanced and explainable low-sample omics deep learning with feature-aggregated multi-channel networks

WX Shen, Y Liu, Y Chen, X Zeng, Y Tan… - Nucleic Acids …, 2022 - academic.oup.com
Omics-based biomedical learning frequently relies on data of high-dimensions (up to
thousands) and low-sample sizes (dozens to hundreds), which challenges efficient deep …

Interrogating lncRNA functions via CRISPR/Cas systems

M S. Zibitt, CCR Hartford, A Lal - RNA biology, 2021 - Taylor & Francis
Long noncoding RNAs (lncRNAs) are an increasing focus of investigation due to their
implications in diverse biological processes and disease. Nevertheless, the majority of …